NickelMaghrebV1, Main, Exploration, bibRecord, 000201

Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer

Identifieur interne : 000201 ( Main/Exploration ); précédent : 000200; suivant : 000202

Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer

Auteurs : Rim Khlifi [Tunisie] ; Pablo Olmedo [Espagne] ; Fernando Gil [Espagne] ; Bouthaina Hammami [Tunisie] ; Amine Chakroun [Tunisie] ; Ahmed Rebai [Tunisie] ; Amel Hamza-Chaffai [Tunisie]

Source :

Science of the total environment [ 0048-9697 ] ; 2013.

RBID : Pascal:13-0215726

Descripteurs français

Pascal (Inist)
- Arsenic, Cadmium, Chrome, Nickel, Carcinogène, Tissu, Malade, Cancer de la tête et du cou, Métal lourd, Age, Sexe, Tabagisme, Exposition professionnelle, Tunisie, Individu sain, Epidémiologie, Médecine du travail, Homme, Distribution, Santé publique, Biodistribution.
Wicri :
- geographic : Tunisie.
- topic : Cadmium, Chrome, Nickel, Métal lourd, Tabagisme, Médecine du travail, Homme, Santé publique.

English descriptors

KwdEn :
- Age, Arsenic, Cadmium, Carcinogen, Chromium, Distribution, Epidemiology, Head and neck cancer, Healthy subject, Heavy metal, Human, Nickel, Occupational exposure, Occupational medicine, Patient, Public health, Sex, Tissue, Tobacco smoking, Tunisia.

Abstract

Chronic exposure to heavy metals has long been recognized as being capable to increase head and neck cancer incidence among exposed human populations. Head and neck cancer is a significant public health issue in Tunisia. The aim of the present study was to evaluate the concentrations of As, Cd, Cr and Ni in healthy and tumor tissues of head and neck cancer patients. Metal concentrations were determined in tumor and healthy tissues of 101 head and neck cancer patients, using Atomic Absorption Spectrometry. The As, Cd, Cr, and Ni levels in tumor tissues were 3.4, 2.5, 1.3 and 1.5 times higher than those of healthy tissues (p<0.05), respectively. Tumor tissue metal levels were higher in men than in women. As and Cd levels in tumor and healthy tissue samples of patients smokers are significantly higher than those of non-smokers (p<0.05). A strong effect of cumulative smoking as expressed in the number of pack per year, and tumor tissue Cd levels were positively associated with three groups of age (<40, 51-60 and >60 years) in both never-smokers and ever-smokers (<20 and ≥20 pack per year). Healthy tissue Cd levels were negatively associated with age in those three groups of smokers. The highest Cd and Cr concentrations among both workers and non-workers were observed in tumor tissues. The Cd and Cr in tissues of farmers, bricklayers and painters were all significantly higher among the workers as compared with the non-workers group. Tissue metal levels have increased due to smoking and occupational exposure. Heavy metal exposure via tobacco smoking and occupational exposures may increase the risk of head and neck in the Tunisian population.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000056
to stream PascalFrancis, to step Curation: 000385
to stream PascalFrancis, to step Checkpoint: 000065
to stream Main, to step Merge: 000204
to stream Main, to step Curation: 000201

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer</title>
<author><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Marine Ecotoxicology, UR 09-03, Sfax University, IPEIS, BP 805</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bioinformatics Unit, Centre of Biotechnology of Sfax, BP 1177</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Legal Medicine and Toxicology, University of Granada</s1>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Grenade (Espagne)</settlement>
<region nuts="2" type="region">Andalousie</region>
</placeName>
<orgName type="university">Université de Grenade</orgName>
</affiliation>
</author>
<author><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Legal Medicine and Toxicology, University of Granada</s1>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Grenade (Espagne)</settlement>
<region nuts="2" type="region">Andalousie</region>
</placeName>
<orgName type="university">Université de Grenade</orgName>
</affiliation>
</author>
<author><name sortKey="Hammami, Bouthaina" sort="Hammami, Bouthaina" uniqKey="Hammami B" first="Bouthaina" last="Hammami">Bouthaina Hammami</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Otorhinolaryngology, HUC Habib Borguiba Hospital</s1>
<s2>Sfax</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chakroun, Amine" sort="Chakroun, Amine" uniqKey="Chakroun A" first="Amine" last="Chakroun">Amine Chakroun</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Otorhinolaryngology, HUC Habib Borguiba Hospital</s1>
<s2>Sfax</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bioinformatics Unit, Centre of Biotechnology of Sfax, BP 1177</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Marine Ecotoxicology, UR 09-03, Sfax University, IPEIS, BP 805</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0215726</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 13-0215726 INIST</idno>
<idno type="RBID">Pascal:13-0215726</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000056</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000385</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000065</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000065</idno>
<idno type="wicri:doubleKey">0048-9697:2013:Khlifi R:arsenic:cadmium:chromium</idno>
<idno type="wicri:Area/Main/Merge">000204</idno>
<idno type="wicri:Area/Main/Curation">000201</idno>
<idno type="wicri:Area/Main/Exploration">000201</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer</title>
<author><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Marine Ecotoxicology, UR 09-03, Sfax University, IPEIS, BP 805</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bioinformatics Unit, Centre of Biotechnology of Sfax, BP 1177</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Legal Medicine and Toxicology, University of Granada</s1>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Grenade (Espagne)</settlement>
<region nuts="2" type="region">Andalousie</region>
</placeName>
<orgName type="university">Université de Grenade</orgName>
</affiliation>
</author>
<author><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Legal Medicine and Toxicology, University of Granada</s1>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Grenade (Espagne)</settlement>
<region nuts="2" type="region">Andalousie</region>
</placeName>
<orgName type="university">Université de Grenade</orgName>
</affiliation>
</author>
<author><name sortKey="Hammami, Bouthaina" sort="Hammami, Bouthaina" uniqKey="Hammami B" first="Bouthaina" last="Hammami">Bouthaina Hammami</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Otorhinolaryngology, HUC Habib Borguiba Hospital</s1>
<s2>Sfax</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chakroun, Amine" sort="Chakroun, Amine" uniqKey="Chakroun A" first="Amine" last="Chakroun">Amine Chakroun</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Otorhinolaryngology, HUC Habib Borguiba Hospital</s1>
<s2>Sfax</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bioinformatics Unit, Centre of Biotechnology of Sfax, BP 1177</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Marine Ecotoxicology, UR 09-03, Sfax University, IPEIS, BP 805</s1>
<s2>3018 Sfax</s2>
<s3>TUN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Tunisie</country>
<wicri:noRegion>3018 Sfax</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Science of the total environment</title>
<title level="j" type="abbreviated">Sci. total environ.</title>
<idno type="ISSN">0048-9697</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Science of the total environment</title>
<title level="j" type="abbreviated">Sci. total environ.</title>
<idno type="ISSN">0048-9697</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term>
<term>Arsenic</term>
<term>Cadmium</term>
<term>Carcinogen</term>
<term>Chromium</term>
<term>Distribution</term>
<term>Epidemiology</term>
<term>Head and neck cancer</term>
<term>Healthy subject</term>
<term>Heavy metal</term>
<term>Human</term>
<term>Nickel</term>
<term>Occupational exposure</term>
<term>Occupational medicine</term>
<term>Patient</term>
<term>Public health</term>
<term>Sex</term>
<term>Tissue</term>
<term>Tobacco smoking</term>
<term>Tunisia</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Arsenic</term>
<term>Cadmium</term>
<term>Chrome</term>
<term>Nickel</term>
<term>Carcinogène</term>
<term>Tissu</term>
<term>Malade</term>
<term>Cancer de la tête et du cou</term>
<term>Métal lourd</term>
<term>Age</term>
<term>Sexe</term>
<term>Tabagisme</term>
<term>Exposition professionnelle</term>
<term>Tunisie</term>
<term>Individu sain</term>
<term>Epidémiologie</term>
<term>Médecine du travail</term>
<term>Homme</term>
<term>Distribution</term>
<term>Santé publique</term>
<term>Biodistribution</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cadmium</term>
<term>Chrome</term>
<term>Nickel</term>
<term>Métal lourd</term>
<term>Tabagisme</term>
<term>Médecine du travail</term>
<term>Homme</term>
<term>Santé publique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Chronic exposure to heavy metals has long been recognized as being capable to increase head and neck cancer incidence among exposed human populations. Head and neck cancer is a significant public health issue in Tunisia. The aim of the present study was to evaluate the concentrations of As, Cd, Cr and Ni in healthy and tumor tissues of head and neck cancer patients. Metal concentrations were determined in tumor and healthy tissues of 101 head and neck cancer patients, using Atomic Absorption Spectrometry. The As, Cd, Cr, and Ni levels in tumor tissues were 3.4, 2.5, 1.3 and 1.5 times higher than those of healthy tissues (p<0.05), respectively. Tumor tissue metal levels were higher in men than in women. As and Cd levels in tumor and healthy tissue samples of patients smokers are significantly higher than those of non-smokers (p<0.05). A strong effect of cumulative smoking as expressed in the number of pack per year, and tumor tissue Cd levels were positively associated with three groups of age (<40, 51-60 and >60 years) in both never-smokers and ever-smokers (<20 and ≥20 pack per year). Healthy tissue Cd levels were negatively associated with age in those three groups of smokers. The highest Cd and Cr concentrations among both workers and non-workers were observed in tumor tissues. The Cd and Cr in tissues of farmers, bricklayers and painters were all significantly higher among the workers as compared with the non-workers group. Tissue metal levels have increased due to smoking and occupational exposure. Heavy metal exposure via tobacco smoking and occupational exposures may increase the risk of head and neck in the Tunisian population.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>Tunisie</li>
</country>
<region><li>Andalousie</li>
</region>
<settlement><li>Grenade (Espagne)</li>
</settlement>
<orgName><li>Université de Grenade</li>
</orgName>
</list>
<tree><country name="Tunisie"><noRegion><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name>
</noRegion>
<name sortKey="Chakroun, Amine" sort="Chakroun, Amine" uniqKey="Chakroun A" first="Amine" last="Chakroun">Amine Chakroun</name>
<name sortKey="Hammami, Bouthaina" sort="Hammami, Bouthaina" uniqKey="Hammami B" first="Bouthaina" last="Hammami">Bouthaina Hammami</name>
<name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name>
<name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name>
<name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name>
</country>
<country name="Espagne"><region name="Andalousie"><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name>
</region>
<name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/NickelMaghrebV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000201 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000201 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Terre
   |area=    NickelMaghrebV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:13-0215726
   |texte=   Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer
}}

This area was generated with Dilib version V0.6.27.
Data generation: Fri Mar 24 23:14:20 2017. Site generation: Tue Mar 5 17:03:47 2024

	Serveur d'exploration sur le nickel au Maghreb
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le nickel au Maghreb

Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer

Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri